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In some control wells permeabilisation was assessed by subsequent incubation with 0.4% Eosin Y in lysis buffer for 5 min at 37 C, which stained more than 90% of cells (compared with less than 5% of cells stained in wells not exposed to the toxin)

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3 provides an experimental platform for the parameterisation of the mathematical models

In inducing apoptosis in human lymphoma cells, Sag has shown to selectively activate programmed cell death in sensitive cell lines, providing evidence for its potential as a new inducer of lymphoma cell apoptosis